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New York · 25 October 2026 · nbcnewyork.com

Flu Season Arrives Unusually Early as Mutated H1N1 Strain Spreads Across the U.S.

Health officials are warning of an atypically early start to the 2026–27 flu season, driven by a mutated influenza A H1N1 strain first detected in Seattle in September that may partially evade vaccine-based and prior-infection immunity.

The United States is experiencing an unusually early start to the 2026–27 flu season, with the CDC's FluView report for the week ending October 17 showing activity running higher than typical for this time of year. The primary driver is an influenza A H1N1 strain — subclade D.3.1.1 — that acquired a new mutation, G155E, first detected in September 2026 in Seattle, Washington. Public health officials warn that this mutation sits at a site critical for generating protective antibodies, meaning the strain may partially evade immunity built through prior infection or vaccination against older H1N1 variants. Because the mutated strain differs significantly from the H3N2 variant that dominated the previous winter, even people who contracted flu last year may be at elevated risk. Health authorities across New York and the broader tri-state area are urging residents to receive the updated 2026–2027 flu vaccine, available at most pharmacies, doctors' offices, and clinics. No specific hospitalisation surge in New York has been reported yet, but officials say the early seasonal trajectory is concerning and warrants prompt vaccination.

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